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Actin mixes up mitochondria for inheritance - Nature.com

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RESEARCH SUMMARY

Actin mixes up mitochondria for inheritance

In cells that divide symmetrically, a meshwork of actin cables is shown to maintain the uniform distribution of mitochondria around the mitotic spindle. Actin clouds and comet tails are assembled dynamically to shuffle mitochondria locally and ensure the equal and random inheritance of these organelles by the two daughter cells.
  1. Andrew S. Moore

    1. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA..The Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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  2. Erika L. F. Holzbaur

    1. Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.The Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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This is a summary of Moore, A. S. et al. Actin cables and comet tails organize mitochondrial networks in mitosis. Nature https://doi.org/10.1038/s41586-021-03309-5 (2021).

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doi: https://doi.org/10.1038/d41586-021-01115-7

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Competing Interests

The authors declare no competing interests.

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Actin mixes up mitochondria for inheritance - Nature.com
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